Extend Your Life.
Elevate Your Living.
HealthSpan Therapeutics is developing next-generation biologics designed to improve muscle health, metabolic function, and overall vitality.
The Problem
Muscle loss is a hidden epidemic
1-2%
of muscle mass lost per year after age 40 — silently compounding across decades
500M+
2.5x
~1 in 3
The GLP-1 Effect
Up to 40% of weight lost on GLP-1s can be lean mass
GLP-1 weight loss drugs are now among the most prescribed medications in the world. But accelerated muscle loss is an underrecognized consequence — worsening metabolic dysfunction, frailty, and long-term health outcomes. Addressing this gap is urgent.
Why It Matters
Muscle is the body's largest metabolic and endocrine-signaling organ
Four Critical Systems
Metabolic
Glucose & energy regulation
Improves insulin sensitivity and glycemic control
Increases basal metabolic rate, even at rest
Primary site for glucose uptake and fat oxidation
Endocrine
Hormonal & systemic signaling
Secretes myokines regulating fat metabolism, glucose, inflammation, bone, and brain function
Central endocrine regulator of whole-body metabolic health
Loss of muscle mass leads to systemic hormonal dysregulation
Bone
Skeletal integrity & density
Mechanical loading by muscle stimulates bone formation and strength
Muscle-derived myokines increase bone density
Preserved muscle mass reduces the risk of osteoporosis and fractures
Frailty
Independence & quality of life
Muscle strength and mass strongly predict mobility, independence, and quality of life
Muscle loss is a key driver of frailty and functional decline
Poor muscle health worsens surgical and cancer treatment outcomes, prolonging hospitalization